One third of the deaths each year in the United States due to the complications of untreated essential hypertension are stroke deaths, 1 and hypertensive individuals are reported to have a greater incidence of stroke than normotensive individuals. This association does not appear to be mediated by established stroke risk factors, specifically blood pressure levels or hypertension status. The GNβ3 825T allele was not significantly associated with clinical stroke in blacks for either adjustment model.Ĭonclusions-The GNβ3 gene 825C/T polymorphism is significantly associated with incident clinical ischemic stroke in a white middle-aged American population, but not in blacks. The GNβ3 825T allele was significantly associated with clinical stroke in whites after adjustment for age and sex (hazard rate ratio, 1.45 95% CI, 1.05 to 2.00) and after further adjustment for multiple stroke risk factors (hazard rate ratio, 1.68 95% CI, 1.18 to 2.41). The ADD1 W460 allele was also not a significant predictor of clinical stroke. The ADD1 W460 and GNβ3 825T alleles were not significantly associated with subclinical stroke. The frequency of the GNβ3 825T allele was determined in whites and blacks, respectively, for the subclinical cases (0.26, 0.73), MRI-CRS (0.31, 0.75), clinical cases (0.36, 0.72), and CRS (0.30, 0.72). Results-The frequency of the ADD1 W460 allele was determined for the subclinical cases (0.12), MRI-CRS (0.16), clinical cases (0.14), and CRS (0.17). A stratified random sample of the ARIC cohort (CRS) (n=984) was used as the comparison group for the clinical cases. Incidence of clinical ischemic stroke was determined by following the ARIC cohort for an average of 7.2 years for potential cerebrovascular events 231 validated clinical ischemic strokes were identified. Subclinical cerebral infarct cases (n=202) were compared with a stratified random sample (MRI-CRS) identified from individuals participating in the MRI examination (n=211). Methods-Subclinical stroke was determined by cerebral MRI.

For this reason, we sought to examine the association between the α-adducin ( ADD1) G/W460 and G-protein β3 subunit ( GNβ3) 825C/T polymorphisms and subclinical and clinical stroke in the Atherosclerosis Risk in Communities (ARIC) Study. Genes contributing to interindividual variation in blood pressure levels and essential hypertension status may play a role in the etiology of stroke either through their effects on blood pressure levels or through separate pathways. Customer Service and Ordering Informationīackground and Purpose-Essential hypertension is a significant risk factor for stroke.Stroke: Vascular and Interventional Neurology.Journal of the American Heart Association (JAHA).Circ: Cardiovascular Quality & Outcomes.Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB).

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